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Product Name Anti-CD2/Cy7 Chinese Name Cy7标记的CD2抗体 Alias T-cell surface antigen CD2; CD 2; CD2 antigen; CD2 molecule; LFA2; LFA3 receptor; Lymphocyte function antigen 2; p50; Rosette receptor; Sheep erythrocyte receptor; Sheep red blood cell receptor; SRBC; T cell surface antigen CD2; T cell surface antigen T11/Leu 5; T11; CD2_HUMAN. Research Area Cell biology immunology Stem cells Cell Surface Molecule glycoprotein Natural killer cells lymphocyte t-lymphocyte b-lymphocyte Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, Dog, Pig, Horse, ) Applications
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 37kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CD2 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
CD2 is a surface antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes.
CD2 interacts with lymphocyte function associated antigen (LFA3) and CD48/BCM1 to mediate adhesion between T cells and other cell types. CD2 is implicated in the triggering of T cells, the cytoplasmic domain is implicated in the signaling function. It is useful for the identification of lymphomas and leukaemias of T cell origin.
Function:
CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
Subunit:
Interacts with CD2AP. Interacts with PSTPIP1.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Database links:Entrez Gene: 914 Human
Entrez Gene: 12481 Mouse
Omim: 186990 Human
SwissProt: P06729 Human
SwissProt: P08920 Mouse
Unigene: 523500 Human
Unigene: 22842 Mouse
Unigene: 10328 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CD2分子又称T11、绵羊红细胞受体(ER)、lymphocyte功能相关抗原2(LFA-2)和Leu5,是人Tlymphocyte表面的单链glycoprotein.CD2分子是分布于胸腺细胞及所有成熟Tlymphocyte和大部分Natural killer cells表面的特征性分化抗原。CD2具有调节Tlymphocyte分化、成熟、激活和凋亡等功能,CD2与LFA-3之间的粘附功能对于TlymphocyteTCR识别外来抗原与APC细胞表面MHC抗原复合物、Tumour抗原、病毒感染靶细胞以及同种异体抗原均有重要的辅助作用。
最近研究表明,CD48和CD59也是CD2的配体,参与T细胞的粘附和细胞间的相互作用,此外,CD2可以与其它膜分子如CD44、CD45的功能有关。CD2具有对T细胞的旁路激活途径作用。
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