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Rabbit Anti-SHFM1/DSS1/Cy5 Conjugated antibody
Rabbit Anti-SHFM1/DSS1/Cy5 Conjugated antibody
26S proteasome complex subunit DSS1; Deleted in split hand/split foot 1; Deleted in Split-Hand/Split-Foot 1 region; ECD; SEM1; SHFD1; DSS1_HUMAN; SHFM1; SHSF1; Split hand/foot deleted protein 1; Split hand/foot malformation (ectrodactyly) type 1; Split ha
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Product Name Anti-SHFM1/DSS1/Cy5
Chinese Name Cy5标记的先天性裂手/裂足畸形相关蛋白DSS1抗体
Alias 26S proteasome complex subunit DSS1; Deleted in split hand/split foot 1; Deleted in Split-Hand/Split-Foot 1 region; ECD; SEM1; SHFD1; DSS1_HUMAN; SHFM1; SHSF1; Split hand/foot deleted protein 1; Split hand/foot malformation (ectrodactyly) type 1; Split hand/foot malformation type 1 protein.  
Research Area Cell biology  Developmental biology  Cyclin  Ubiquitin  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Pig, Cow, Rabbit, )
Applications ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 8.3kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human DSS1
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle. [provided by RefSeq, Jul 2008]

Function:
The gene for DSS1 has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. DSS1 has been proposed to be a candidate for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle.

Subunit:
Part of the 26S proteasome. Interacts with the C-terminal of BRCA2.

Tissue Specificity:
Expressed in limb bud, craniofacial primordial and skin.

Similarity:
Belongs to the DSS1/SEM1 family.

Database links:

Entrez Gene: 7979 Human

Omim: 601285 Human

SwissProt: P60896 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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