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Product Name Anti-NPAS3/Cy5 Chinese Name Cy5标记的神经细胞PAS结构域蛋白3抗体 Alias Basic helix loop helix PAS protein MOP6; Basic-helix-loop-helix-PAS protein MOP6; bHLHe12; Class E basic helix-loop-helix protein 12; FLJ10003; FLJ11138; FLJ11605; Member of PAS protein 6; MOP 6; MOP6; Neuronal PAS domain containing protein 3; Neuronal PAS domain protein 3; Neuronal PAS domain-containing protein 3; Neuronal PAS3; NPAS 3; NPAS3; NPAS3_HUMAN; PAS domain-containing protein 6; PASD 6; PASD6. Research Area Neurobiology Signal transduction transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 101kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human NPAS3 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The Per-Arnt-Sim (PAS) domain is a 270 amino acid motif that mediates associations among various PAS family transcription factors. The PAS family contains neuronal specific transcription factors known as NPAS1, NPAS2 and NPAS3, which are involved the development and maintenance of learning and memory pathways. NPAS1 regulates erythropoietin expression in developing brain. NPAS2, also designated PAS 4/MOP4, associates with MOP3 to activate transcription. NPAS3, which localizes to the nucleus and is ubiquitously expressed in the adult brain, may be involved in neurogenesis and may control regulatory pathways relevant to psychotic illness and to schizophrenia. It regulates tracheal cell fates in the embryo and is necessary for the development of the posterior spiracles and the salivary gland duct. NPAS3 contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. Efficient DNA binding by NPAS2 requires dimerization with another bHLH protein.
Function:
May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness.
Subunit:
Efficient DNA binding requires dimerization with another bHLH protein.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitously expressed in the adult brain.
DISEASE:
Note=A chromosomal aberration involving NPAS3 is found in a family with schizophrenia. Translocation t(9;14)(q34;q13).
Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.
Contains 1 PAC (PAS-associated C-terminal) domain.
Contains 2 PAS (PER-ARNT-SIM) domains.
Database links:
UniProtKB/Swiss-Prot: Q8IXF0.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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