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Product Name Anti-PSA (PA5)/Cy5 Chinese Name Cy5标记的鼠抗人前列腺特异性抗原单克隆抗体(检测) Alias antigen, prostate-specific; APS; Gamma seminoprotein; Gamma-seminoprotein; hK3; Kallikrein 3; Kallikrein 3, (prostate specific antigen); Kallikrein related peptidase 3; Kallikrein-3; KLK 3; KLK2A1; KLK3; KLK3_HUMAN; P 30 antigen; P-30 antigen; P30 antigen; Prostate Specific Antigen; Prostate-specific antigen; PSA; Semenogelase; Seminin. Research Area Tumour Immunogen Species Mouse Clonality Monoclonal Clone NO. PA5 React Species Human, Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 23kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen Full length native protein purified from human Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Function:
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
Subunit:
Forms heterodimer with SERPINA5.
Subcellular Location:
Secreted.
Tissue Specificity:
Prostate.
Similarity:
Belongs to the peptidase S1 family. Kallikrein subfamily.
Contains 1 peptidase S1 domain.
Database links:Entrez Gene: 354 Human
Omim: 176820 Human
SwissProt: P07288 Human
Unigene: 171995 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PSA-前列腺特异性抗原为激肽释放酶家族蛋白,为丝氨酸蛋白酶,由前列腺上皮产生,精液中的浓度很高,可使精液凝块水解、液化,功能与男性生育力有关.
此抗体可用于试剂盒检测用抗体。
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