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Product Name Anti-VEGF-B/Cy5 Chinese Name Cy5标记的血管内皮生长因子B抗体 Alias Vascuoar endothelial growth factor B; Vegfb; VEGF-B; VEGF B; VEGFB 167; Vrf; VEGF-related factor; VRF; VEGFB_HUMAN. Research Area Tumour Cell biology immunology Neurobiology Growth factors and hormones Kinases and Phosphatases The cell membrane受体 vascular endothelial cell Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, ) Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 20kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human VEGFB Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]
Function:
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
Subunit:
Homodimer; disulfide-linked. Can also form heterodimer with VEGF.
Subcellular Location:
Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
Tissue Specificity:
Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.
Post-translational modifications:
VEGF-B186 is O-glycosylated.
Similarity:
Belongs to the PDGF/VEGF growth factor family.
Database links:Entrez Gene: 7423 Human
Entrez Gene: 22340 Mouse
Omim: 601398 Human
SwissProt: P49765 Human
SwissProt: P49766 Mouse
Unigene: 78781 Human
Unigene: 15607 Mouse
Unigene: 198550 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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