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Product Name Anti-IL17F/Cy5 Chinese Name Cy5标记的白介素-17F抗体 Alias IL-17F; C49A; FISP; IL 24; IL 4 induced secreted protein; IL-24; IL10B; Il24; IL17F_HUMAN; interleukin 24; Interleukin-24; MDA-7; MDA7; Melanocyte associated Mda 7; Melanoma differentiation association protein 7; Melanoma differentiation-associated gene 7 protein; Mob5; ST16; Suppression of tumorigenicity 16 (melanoma differentiation); Suppression of tumorigenicity 16; Suppression of tumorigenicity 16 protein; Research Area Cell biology immunology Cell Surface Molecule t-lymphocyte Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 17kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human IL-17F Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]
Function:
Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis.
Subunit:
Homodimer; disulfide-linked.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.
DISEASE:
Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6) [MIM:613956]. CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
Similarity:
Belongs to the IL-17 family.
Database links:Entrez Gene: 112744 Human
Omim: 606496 Human
SwissProt: Q96PD4 Human
Unigene: 272295 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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