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Product Name Anti-TLR11/Cy5 Chinese Name Cy5标记的Toll样受体11抗体 Alias Toll like receptor 11; Gm287; MGC129352; MGC129353; RGD1564460; TLR11_MOUSE. Research Area immunology The cell membrane受体 Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Mouse, Rat, Horse, Rabbit, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 99kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse TLR11 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Toll like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR11 is one of three mouse TLRs that lack a human ortholog. It is activated specifically by uropathogenic bacteria, and mice lacking TLR11 showed a much greater susceptability to uropathogenic infections, indicating a potentially important role for TLR11 in preventing infections in the urogenital system.
Function:
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Subunit:
Binds MYD88 via their respective TIR domains. Interacts with HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Similarity:
Belongs to the Toll-like receptor family.
Contains 10 LRR (leucine-rich) repeats.
Contains 1 TIR domain.
Database links:Entrez Gene: 239081 Mouse
SwissProt: Q6R5P0 Mouse
Unigene: 291512 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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