Product Name	Anti-LRRC17/Cy5.5
Chinese Name	Cy5.5标记的富含亮氨酸重复蛋白17抗体
Alias	37 kDa leucine rich repeat (LRR) protein; 37kDa; 4833425M04Rik; 6130400C22Rik; Leucine-rich repeat-containing protein 17; LRC17_HUMAN; LRRC17; p37NB; UNQ3076/PRO9909.
Research Area	Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	50kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LRRC17
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: LRRC17 is a 441 amino acid protein that localizes to the cytoplasm and contains six LRR repeats. The protein is expressed at high levels in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and lung. LRRC17 is expressed at higher levels in non-neuronal (S-type) neuroblastoma cells than in neuroblastic (N-type) neuroblastoma cells. Function: Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors. Subcellular Location: Secreted; extracellular space. Tissue Specificity: Expressed in osteoblast cell lines. Well expressed in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and lung and only at the basal levels in the other tissues examined including adult kidney. More expressed in S-type neuroblastoma cells than in N-type neuroblastoma cells. Similarity: Contains 6 LRR (leucine-rich) repeats. Contains 2 LRRCT domains. Contains 1 LRRNT domain. Database links: Entrez Gene: 10234 Human Entrez Gene: 777690 Cow Entrez Gene: 100050177 Horse Entrez Gene: 74511 Mouse Entrez Gene: 100737774 Pig Entrez Gene: 100340395 Rabbit Entrez Gene: 502715 Rat SwissProt: Q8N6Y2 Human SwissProt: Q9CXD9 Mouse Unigene: 567412 Human Unigene: 439963 Mouse Unigene: 207235 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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