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Rabbit Anti-PCDHGB5/AF594 Conjugated antibody
Rabbit Anti-PCDHGB5/AF594 Conjugated antibody
PCDH gamma B5; PCDHGB 5; Protocadherin gamma B5; Protocadherin gamma subfamily B 5; PCDGH_HUMAN.
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Details

Product Name Anti-PCDHGB5/AF594
Chinese Name AF594标记的原钙粘蛋白γB5抗体
Alias PCDH gamma B5; PCDHGB 5; Protocadherin gamma B5; Protocadherin gamma subfamily B 5; PCDGH_HUMAN.  
Research Area Tumour  Cell biology  Neurobiology  Signal transduction  Cell adhesion molecule  Cell Surface Molecule  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, )
Applications ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 97kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human PCDHGB5
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
PCDHGB5 is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein (By similarity).

Similarity:
Contains 6 cadherin domains.

Database links:

Entrez Gene: 56101 Human

Omim: 606302 Human

SwissProt: Q9Y5G0 Human

SwissProt: Q9Y5G0-2 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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