Product Name	Anti-RLLM1/AF594
Chinese Name	AF594标记的胰腺癌转移相关蛋白RLLM1抗体
Alias	CGI 99; CGI99; CLE; Homeobox prox 1; RLLM1; Chromosome 14 open reading frame 166; CLE7; LCRP369; RLL motif containing 1; CN166_HUMAN.
Research Area	Tumour  Chromatin and nuclear signals  Neurobiology  Signal transduction  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	28kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human RLLM1/C14orf166 (188-230aa)
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
Product Detail	background: CGI-99 is a 244 amino acid protein that localizes to the nucleus, as well as to the cytoplasm, and belongs to the UPF0568 family. Expressed in a variety of tissues with particularly high levels in heart and skeletal muscle, CGI-99 functions as a homodimer that interacts with Ninein and is thought to regulate Ninein function. CGI-99 is overexpressed in brain tumor tissue, suggesting a role in tumor development and metastasis. The gene encoding CGI-99 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction. Function: The function of the C14orf266 gene has not yet been determined, but it is widely expressed, at high levels in heart and skeletal muscle and at intermediate levels in liver, pancreas, foetal brain and foetal lung. It is weakly expressed in adult brain, adult lung, placenta, foetal liver and foetal kidney, and overexpressed in many brain tumors.Cellular localization;Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. centrosome.May localize at the centrosome during mitosis. Subunit: Homodimer (Probable). Interacts with NIN; which may prevent phosphorylation of NIN. Interacts with POLR2A. Component of a tRNA-splicing ligase complex. Interacts with influenza A virus RNA polymerase subunits PA, PB1 and PB2, and nucleocapsid NP. Interacts with hepatitis C virus core protein p19. Subcellular Location: Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, centrosome. Note=May localize at the centrosome during mitosis. Tissue Specificity: Widely expressed. Expressed at high level in heart and skeletal muscle. Expressed at intermediate level in liver, pancreas, fetal brain and fetal lung. Weakly expressed in adult brain, adult lung, placenta, fetal liver and fetal kidney. Overexpressed in many brain tumors. Similarity: Belongs to the UPF0568 family. Database links: Entrez Gene: 51637 Human Entrez Gene: 68045 Mouse Omim: 610858 Human SwissProt: Q9Y224 Human SwissProt: Q9CQE8 Mouse Unigene: 534457 Human Unigene: 21932 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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