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Product Name Anti-FCAR/CD89/AF594 Chinese Name AF594标记的免疫球蛋白A Fc段受体1抗体 Alias CD89; Fc alpha receptor; FCAR; FCAR_HUMAN; IgA Fc receptor; Immunoglobulin alpha Fc receptor. Research Area immunology Cell Surface Molecule Cell type markers Immunogen Species Rabbit Clonality Polyclonal React Species Human, Rat, Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 29kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FCAR Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
Tissue specificity; Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.
Subunit:
Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2.
Subcellular Location:
Isoform A.1: Cell membrane; Single-pass type I membrane protein.
Isoform A.2: Cell membrane; Single-pass type I membrane protein.
Isoform A.3: Cell membrane; Single-pass type I membrane protein.
Isoform B: Secreted.
Isoform B-delta-S2: Secreted.
Tissue Specificity:
Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.
Similarity:
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Database links:
Entrez Gene: 2204 Human
Omim: 147045 Human
SwissProt: P24071 Human
Unigene: 659872 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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