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Product Name Anti-EphA3/AF594 Chinese Name AF594标记的酪氨酸蛋白激酶受体A3抗体 Alias EK4; End3; Eph receptor A3; EPH-like kinase 4; EPH-like tyrosine kinase 1; EphA3; Ephrin receptor EphA3; Ephrin type-A receptor 3; ETK 1; ETK; ETK1; HEK 4; HEK; Hek4; Human embryo kinase; Mek4; MGC109882; Receptor tyrosine kinase HEK; Tyro 4; Tyro4; Tyrosine protein kinase receptor ETK 1; Tyrosine-protein kinase TYRO4; AW492086; Cek4; EC 2.7.10.1; EPHA3_HUMAN. Research Area Tumour Cardiovascular Cell biology Neurobiology Signal transduction Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Rat, (predicted: Human, Dog, Cow, Horse, Sheep, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 106kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human EphA3/Eph receptor A3 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
EphA3 is a member of the Ephrin (Eph) family. The Ephrins and Eph-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the Ephrin A (EphA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the Ephrin B (EphB) class, which are transmembrane proteins. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats.
Function:
Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.
Subunit:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain.
Subcellular Location:
Secreted and Cell membrane.
Tissue Specificity:
Widely expressed. Highest level in placenta.
Post-translational modifications:
Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1. Dephosphorylated by PTPN1.
DISEASE:
Defects in EPHA3 may be a cause of colorectal cancer (CRC)
Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Contains 1 Eph LBD (Eph ligand-binding) domain.
Contains 2 fibronectin type-III domains.
Contains 1 protein kinase domain.
Contains 1 SAM (sterile alpha motif) domain.
Database links:Entrez Gene: 2042 Human
Entrez Gene: 13837 Mouse
Omim: 179611 Human
SwissProt: P29320 Human
SwissProt: P29319 Mouse
Unigene: 123642 Human
Unigene: 1977 Mouse
Unigene: 10713 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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