Product Name	Anti-DLGAP4/AF594
Chinese Name	AF594标记的PSD95Binding protein4抗体
Alias	DLGAP4; DAP 4; DAP-4; DAP4; Discs, large (Drosophila) homolog associated protein 4; Disks large associated protein 4; Disks large-associated protein 4; DLGAP4; DLGP4_HUMAN; DLP4; PSD 95/SAP90 binding protein 4; PSD-95/SAP90-binding protein 4; RP5-977B1.6; SAP90/PSD-95-associated protein 4; SAPAP 4; SAPAP-4; SAPAP4.
Research Area	Neurobiology  Channel protein  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	108kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SAPAP4/DLGAP4
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: A guanylate kinase is a phosphotransferase that produces ADP and GDP from the substrates ATP and GMP. SAPAP4 is a 992 amino acid protein that likely localizes to the postsynaptic membrane of neurons to enhance neuronal signaling. SAPAP4 could act as a signaling molecule which interacts with the human genes DLG1 and DLG4/PSD-95. The gene encoding SAPAP4, DLGAP4, maps to human chromosome 20. Comprising approximately 2% of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought important for seminal production and may be potential targets for male contraception. Function: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Subunit: Interacts with DLG1 and DLG4/PSD-95 (By similarity). Subcellular Location: Membrane; Peripheral membrane protein (By similarity). Similarity: Belongs to the SAPAP family. Database links: Entrez Gene: 22839 Human Entrez Gene: 228836 Mouse Entrez Gene: 286930 Rat SwissProt: Q9Y2H0 Human SwissProt: B1AZP2 Mouse SwissProt: P97839 Rat Unigene: 249600 Human Unigene: 22094 Mouse Unigene: 11279 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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