Product Name	Anti-SFTPA1/AF594
Chinese Name	AF594标记的肺表面活性蛋白A抗体
Alias	SP-A；Surfactant Protein A; pulmonary surfactant-associated glycoprotein A; Pulmonary surfactant-associated protein A2 precursor; SP-A2; PSP-A; PSPA; Alveolar proteinosis protein; 35 kDa pulmonary surfactant-associated protein; COLEC4; MGC133365; Pulmonary surfactant apoprotein; Pulmonary surfactant associated protein; SFTP1; SFTPA; SFTPA1; SFTPA1B; SP A; SP A1; Surfactant pulmonary associated protein A1; SFTPA_MOUSE; Collectin-5; Sftp-1.
Research Area
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Mouse, Rat, Guinea Pig, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	25kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse SFTPA
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009]. Function: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Subunit: Oligomeric complex of 6 set of homotrimers. Subcellular Location: Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film. DISEASE: Defects in SFTPA2 are a cause of pulmonary fibrosis idiopathic (IPF) [MIM:178500]. Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease. Similarity: Belongs to the SFTPA family. Contains 1 C-type lectin domain. Contains 1 collagen-like domain. Database links: Entrez Gene: 610540 Dog Entrez Gene: 653509 Human Entrez Gene: 20387 Mouse Omim: 178630 Human SwissProt: P06908 Dog SwissProt: Q8IWL2 Human Unigene: 535295 Human   Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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