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Product Name Anti-PCDH10/AF594 Chinese Name AF594标记的原钙粘附蛋白10抗体 Alias DKFZp761O2023; KIAA1400; MGC133344; OL PCDH; Ortholog of OL pcdh; OTTHUMP00000220001; PCD10_HUMAN; PCDH10; PCDH19; Protocadherin 10; Protocadherin-10. Research Area Tumour Cell biology Neurobiology Signal transduction Cell adhesion molecule Immunogen Species Rabbit Clonality Polyclonal React Species Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 110kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PCDH10 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDH10 (protocadherin 10), also known as PCDH19 or OL-PCDH, is a 1,040 amino acid single-pass type I membrane protein that contains six cadherin domains and one transmembrane domain. Expressed at moderate levels in brain, ovary and testis and present at lower levels in all other tissues, PCDH10 functions as a calcium-dependent cell-adhesion protein that may function as a tumor suppressor. When underexpressed, PCDH10 is associated with the progression of various carcinomas, including gastric cancer.
Function:
Potential calcium-dependent cell-adhesion protein.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Moderately expressed in all regions of the brain examined, as well as in testis and ovary, and low expression in all other tissues tested.
Similarity:
Contains 6 cadherin domains.
Database links:Entrez Gene: 57575 Human
Entrez Gene: 18526 Mouse
Omim: 608286 Human
SwissProt: Q9P2E7 Human
Unigene: 192859 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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