TEL: +86 571 56623320 EMAIL: [email protected]
Product Name Anti-Claudin 18/AF594 Chinese Name AF594标记的紧密连接蛋白18抗体 Alias Claudin 18; Claudin-18; CLD18_HUMAN; CLDN18; SFTA5; SFTPJ. Research Area Cell biology Signal transduction Transporter Cell adhesion molecule endothelial cells Transmembrane protein Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Rat, Pig, Rabbit, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 28kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Claudin 18 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The Claudin superfamily consists of many structurally related proteins in humans (1). These proteins are important structural and functional components of tight junctions in paracellular transport (1,2). Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues (1). Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecule (3). Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands (4). Emerging evidence suggests that the Claudin family of proteins regulates transport through tight junctions via differential discrimination for solute size and charge (5).Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions (6).
Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Subcellular Location:
Cell junction > tight junction. Cell membrane.
Tissue Specificity:
Concentrated at the cell-cell borders of epithelial cells.
Similarity:
Belongs to the claudin family.
Database links:Entrez Gene: 51208 Human
Entrez Gene: 56492 Mouse
Omim: 609210 Human
SwissProt: P56856 Human
SwissProt: P56857 Mouse
Unigene: 655324 Human
Unigene: 386784 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Scan Wechat Qrcode