Product Name	Anti-CREBL2/AF594
Chinese Name	AF594标记的环腺苷酸应答元件Binding protein样蛋白2抗体
Alias	cAMP responsive element binding protein like 2; CREBL 2; MGC117311; MGC138362; MHBs-binding protein 1; CRBL2_HUMAN.
Research Area	Tumour  Cell biology  Chromatin and nuclear signals  Signal transduction  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	14kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CREBL2
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008] Function: CREBL2 is frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. Subunit: Interacts with CREB1; regulates CREB1 phosphorylation, stability and transcriptional activity (By similarity). Subcellular Location: Nuclear Post-translational modifications: Phosphorylated by AMPK. Similarity: Belongs to the bZIP family. ATF subfamily. Contains 1 bZIP (basic-leucine zipper) domain. Database links: Entrez Gene: 1389 Human Entrez Gene: 537195 Cow Entrez Gene: 232430 Mouse Entrez Gene: 362453 Rat Entrez Gene: 100038265 Xenopus tropicalis Omim: 603476 Human SwissProt: Q0VD32 Cow SwissProt: O60519 Human SwissProt: Q32M00 Mouse SwissProt: Q5BJU6 Rat SwissProt: A4IGK3 Xenopus tropicalis Unigene: 591156 Human Unigene: 267010 Mouse Unigene: 107553 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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