Product Name	Anti-DENND1A/AF594
Chinese Name	AF594标记的DENND1A蛋白抗体
Alias	Connecdenn 1; Connecdenn; DEN1A_HUMAN; DENN domain-containing protein 1A; DENN/MADD domain containing 1A; dennd1a; FAM31A; FLJ21129; FLJ38464; KIAA1608; OTTHUMP00000022090; Protein FAM31A; RP11 230L22.3.
Research Area	Cell biology  Neurobiology  Signal transduction  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	110kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DENND1A
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010] Function: Guanine nucleotide exchange factor (GEF) for RAB35. May be involved in the clathrin-mediated endocytosis of synaptic vesicles. Subcellular Location: Cell junction > synapse > presynaptic cell membrane. Cytoplasmic vesicle > clathrin-coated vesicle membrane. Also associated with uncoated vesicles. Similarity: Contains 1 dDENN domain. Contains 1 DENN domain. Contains 1 uDENN domain. Database links: Entrez Gene: 57706 Human Omim: 613633 Human SwissProt: Q8TEH3 Human Unigene: 568340 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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