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Product Name Anti-FRYL/AF594 Chinese Name AF594标记的FRYL蛋白抗体 Alias 2010313D22Rik; 2310004H21Rik; 2510002A14Rik; 9030227G01Rik; AF4P12; AI930088; ALL fused gene from chromosome 4p12; ALL1-fused gene from chromosome 4p12 protein; DKFZp686E205; FLJ161772; FRYL_HUMAN; FRY like; Furry homolog like (Drosophila); Furry homolog like; Furry like; KIAA0826; mKIAA0826; Protein furry homolog-like. Research Area Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 339kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FRYL Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
FRYL plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis. It regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching. FRYL May function as a transcriptional activator.
Function:
Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator.
Tissue Specificity:
Widely expressed with higher expression in colon, placenta, brain and cells of lymphoid origin.
DISEASE:
Note=A chromosomal aberration involving FRYL is found in treatment-related acute lymphoblastic leukemia (ALL). Translocation t(4;11)(p12;q23) that forms a KMT2A/MLL1-FRYL fusion protein.
Similarity:
Belongs to the furry protein family.
Database links:Entrez Gene: 285527 Human
Entrez Gene: 72313 Mouse
SwissProt: O94915 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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