Product Name	Anti-ZZZ3/AF594
Chinese Name	AF594标记的Zinc finger proteinZZZ3抗体
Alias	ATAC component 1 homolog; ATAC1; DKFZp313N0119; DKFZp564I052; FLJ10362; Zinc finger ZZ domain containing 3; Zinc finger ZZ type containing 3; ZZ type zinc finger containing protein 3; ZZ-type zinc finger-containing protein 3; ZZZ 3; ZZZ3; ZZZ3_HUMAN.
Research Area	Cell biology  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	102kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ZZZ3
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: ZZZ3 (ZZ-type zinc finger-containing protein 3) is a 903 amino acid protein that contains one HTH myb-type DNA-binding domain and one ZZ-type zinc finger. Phosphorylated upon DNA damage by ATM or ATR, ZZZ3 is a subunit of the ATAC complex, which is composed of GCN5, CRP2BP, ADA3, TADA2L, DR1, CCDC101, YEATS2, WDR5 and MBIP. The ATAC complex has histone acetyltransferase activity on histones H3 and H4. ZZZ3 is expressed as four isoforms produced by alternative splicing and is encoded by a gene mapping to human chromosome 1. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. Function: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Subunit: Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 HTH myb-type DNA-binding domain. Contains 1 ZZ-type zinc finger. Database links: Entrez Gene: 26009 Human SwissProt: Q8IYH5 Human Unigene: 480506 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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