TEL: +86 571 56623320 EMAIL: [email protected]
Product Name Anti-TRF4-2/AF594 Chinese Name AF594标记的拓扑异构酶相关功能蛋白4-2抗体 Alias PAP-associated domain-containing protein 5; Terminal uridylyltransferase 3; Topoisomerase related function protein 4-2; TRF4-2; PAPD5_HUMAN; TUTase 3. Research Area transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 63kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TRF4-2 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion
Function:
Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion.
Subunit:
Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase
Subcellular Location:
Nuclear
Similarity:
Belongs to the DNA polymerase type-B-like family.
Contains 1 PAP-associated domain.
Database links:Entrez Gene: 64282 Human
Omim: 605540 Human
SwissProt: Q8NDF8 Human
Unigene: 514342 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Scan Wechat Qrcode