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Product Name Anti-KCNH3/AF594 Chinese Name AF594标记的KCNH3蛋白抗体 Alias BEC1; Brain-specific eag-like channel 1; ELK channel 2; ELK2; Ether-a-go-go-like potassium channel 2; Kv12.2; Melk2; Potassium voltage-gated channel, subfamily H (eag-related), member 3; Voltage-gated potassium channel subunit Kv12.2. Research Area Cell biology Neurobiology Signal transduction Channel protein Immunogen Species Rabbit Clonality Polyclonal React Species Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 117kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human KCNH3 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Voltage gated potassium (Kv) channels represent the most complex class of voltage gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. KCNH3 is a pore forming (alpha) subunit of voltage-gated potassium channel. It elicits an outward current with fast inactivation.
Subunit:
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.
Subcellular Location:
Membrane; Multipass membrane protein.
Tissue Specificity:
Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus.
Similarity:
Contains 1 cyclic nucleotide-binding domain.
Contains 1 PAC (PAS-associated C-terminal) domain.
Contains 1 PAS (PER-ARNT-SIM) domain.
Database links:Entrez Gene: 23416 Human
Entrez Gene: 16512 Mouse
Omim: 604527 Human
SwissProt: Q9ULD8 Human
SwissProt: Q9WVJ0 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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