Product Name	Anti-Nrif1/AF594
Chinese Name	AF594标记的神经营养因子受体相互作用因子1抗体
Alias	Neurotrophin receptor-interacting factor 1; receptor-interacting factor; Nrif1; Nrif; NRIF1_MOUSE; Zinc finger protein 110; Zfp110.
Research Area	transcriptional regulatory factor  Zinc finger protein  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Mouse, Rat, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	94kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse Nrif1
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Zfp110 (zinc finger protein 110) contains 1 SCAN box domain. The SCAN domain has been shown to be able to mediate homo- and hetero-oligomerisation. Function: Transcription regulator involved in NGFR/p75(NTR)-mediated apoptosis. Essential component of the NGFR/p75(NTR) apoptotic pathway: upon ligand-binding and subsequent cleavage of NGFR/p75(NTR), binds to the intracellular domain (ICD) cleavage product of NGFR/p75(NTR), translocates to the nucleus and induces apoptosis, possibly by regulating expression of key regulators of apoptosis. Induces NGFR/p75(NTR)-mediated apoptosis in retina and sympathetic neurons. May also regulate expression of neuronal cholesterol biosynthesis genes. Probably acts as a transcription repressor: specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. Subunit: Interacts with NGFR/p75(NTR). Interacts (via KRAB 1 domain) with TRAF6. Interacts (when ubiquitinated at Lys-15) with SQSTM1/p62. Tissue Specificity: Ubiquitously expressed at low level. Expressed at higher level in testis. Post-translational modifications: Ubiquitinated by TRAF6 at Lys-15 through 'Lys-63'-linked polyubiquitination. 'Lys-63'-linked polyubiquitination occurs in response to NGFR/p75(NTR) cleavage by gamma-secretase and promotes binding with the ICD cleavage product of NGFR/p75(NTR), followed by tranlocation into the nucleus and subsequent apoptosis. Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 5 C2H2-type zinc fingers. Contains 2 KRAB domains. Contains 1 SCAN box domain. Database links: Entrez Gene: 65020 Mouse Entrez Gene: 308362 Rat SwissProt: Q923B3 Mouse SwissProt: Q4V8E9 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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