Product Name	Anti-RTL1/AF594
Chinese Name	AF594标记的哺乳动物反转录蛋白RTL1抗体
Alias	Mammalian retrotransposon derived protein 1; Mar1; MART1; Paternally expressed gene 11 protein; PEG11; Retrotransposon derived protein PEG11; Retrotransposon like 1; Retrotransposon like protein 1.
Research Area	Cell biology  Developmental biology  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	155kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human RTL1
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene is a retrotransposon-derived, paternally expressed imprinted gene that is highly expressed at the late fetal stage in both the fetus and placenta. It has an overlapping maternally expressed antisense transcript, which contains several microRNAs targeting the transcripts of this gene through an RNA interference (RNAi) mechanism. This gene is essential for maintenance of the fetal capillaries. [provided by RefSeq, Jul 2009] Function: Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta Subcellular Location: Membrane; Multi-pass membrane protein Database links: Entrez Gene: 388015 Human Omim: 611896 Human SwissProt: A6NKG5 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Rtl1 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes. RTL1 is an imprinted gene located in a cluster of imprinted genes on chromosome 14. It is expressed from the paternal chromosome and has an antisense transcript with full complementarity to RTL1, RTL1as, expressed from the maternal chromosome, which acts as a repressor for RTL1. Excessive RTL1 expression and decreased RTL1 expression are relevant to upd14pat-like and upd14mat-like phenotypes, respectively. Paternal and maternal uniparental disomy for chromosome 14 (upd14pat and upd14mat) cause distinct phenotypes; Upd14pat results in a unique phenotype characterized by facial abnormality, a small, bell-shaped thorax and abdominal wall defects, and upd14mat leads to pre- and postnatal growth failure and early onset of puberty.

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