Product Name	Anti-NECAB3/AF594
Chinese Name	AF594标记的神经细胞钙Binding protein抗体
Alias	Neuronal calcium-binding protein; amyloid beta (A4) precursor protein binding, family A, member 2 binding protein; Amyloid beta A4 protein binding family A member 2 binding protein; Amyloid beta A4 protein-binding family A member 2-binding protein; APBA2BP; dJ63M2.4; dJ63M2.5; EFCBP3; N terminal EF hand calcium binding protein 3; N-terminal EF-hand calcium-binding protein 3; NECA3_HUMAN; NECAB3; NECAB3; Nek2 interacting protein 1; Nek2-interacting protein 1; Neuronal calcium binding protein 3; Neuronal calcium-binding protein 3; NIP1; STIP3; Synaptotagmin interacting protein 2; SYTIP2; X11L binding protein 51; X11L-binding protein 51; XB51.
Research Area	Cell biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Cow, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	44kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NECAB3
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta-amyloid. Subcellular Location: Golgi apparatus. Tissue Specificity: Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas. Post-translational modifications: Phosphorylated by NEK2. Similarity: Contains 1 ABM domain. Contains 1 EF-hand domain. Database links: Entrez Gene: 63941 Human Entrez Gene: 311562 Rat Omim: 612478 Human SwissProt: Q96P71 Human Unigene: 516986 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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