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Product Name Anti-PSCD4/AF594 Chinese Name AF594标记的胞粘蛋白4抗体 Alias AI467541; CYH4_HUMAN; CYT4; Cyth4; Cytohesin 4; Cytohesin-4; DJ63G5.1; FLJ00017; PH; PH, SEC7 and coiled coil domain containing protein 4; Pleckstrin homology, SEC7, AND coiled coil domains protein 4; Pscd4; RGD1564842; SEC7 and coiled-coil domain-containing protein 4. Research Area Cell biology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 46kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PSCD4 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The structures of this gene and CYTH1 are very similar. [provided by RefSeq, Aug 2008]
Function:
Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through replacement of GDP with GTP.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Expressed predominantly in peripheral blood leukocytes.
Similarity:
Contains 1 PH domain.
Contains 1 SEC7 domain.
Database links:Entrez Gene: 27128 Human
Omim: 606514 Human
SwissProt: Q9UIA0 Human
Unigene: 170944 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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