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Product Name Anti-PEBP4/AF594 Chinese Name AF594标记的磷脂酰乙醇胺Binding protein4抗体 Alias 1700051A02Rik; 1700081D17Rik; AI429082; CORK 1; CORK1; Cousin of RKIP 1 protein; GWTM1933; hPEBP4; MGC22776; PEBP 4; Phosphatidylethanolamine binding protein 4; PRO4408; Protein cousin of RKIP 1; UNQ1933/PRO4408. Research Area Tumour Cell biology Apoptosis Kinases and Phosphatases Binding protein Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 26kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PEBP4 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The phosphatidylethanolamine (PE)-binding proteins, including PEBP4, are an evolutionarily conserved family of proteins with pivotal biologic functions, such as lipid binding and inhibition of serine proteases (Wang et al., 2004 [PubMed 15302887]).[supplied by OMIM, Dec 2008]
Function:
Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization
Subcellular Location:
Lysosome
Tissue Specificity:
Ubiquitously expressed. Highly expressed in tumor cells.
Similarity:
Belongs to the phosphatidylethanolamine-binding protein family.
Database links:Entrez Gene: 157310 Human
Omim: 612473 Human
SwissProt: Q96S96 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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