Product Name	Anti-TMPRSS3/AF594
Chinese Name	AF594标记的跨膜丝氨酸蛋白酶3抗体
Alias	Deafness autosomal recessive 10; DFNB10; DFNB8; ECHOS1; Gene similar to transmembrane serine protease; MGC130589; Serine protease TADG-12; si:dz69g10.3; TADG12; TMPRSS 3; TMPRSS3; TMPS3_HUMAN; Transmembrane protease serine 3; Tumor associated differentially expressed gene 12 protein; Tumor-associated differentially-expressed gene 12 protein; UNQ323/PRO382.
Research Area	Cell biology  Neurobiology  Transmembrane protein  Ubiquitin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	49kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TMPRSS3
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012] Function: Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro). Subcellular Location: Endoplasmic reticulum membrane. Tissue Specificity: Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas. Post-translational modifications: Undergoes autoproteolytic activation. DISEASE: Defects in TMPRSS3 are the cause of deafness autosomal recessive type 8 (DFNB8) [MIM:601072]. DFNA8 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Defects in TMPRSS3 are the cause of deafness autosomal recessive type 10 (DFNB10) [MIM:605316]. Similarity: Belongs to the peptidase S1 family. Contains 1 LDL-receptor class A domain. Contains 1 peptidase S1 domain. Contains 1 SRCR domain. Database links: Entrez Gene: 64699 Human Entrez Gene: 140765 Mouse Omim: 605511 Human SwissProt: P57727 Human SwissProt: Q8K1T0 Mouse Unigene: 208600 Human Unigene: 214638 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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