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Product Name Anti-SH3D19/AF594 Chinese Name AF594标记的SH3D19抗体 Alias ADAM-binding protein Eve-1; EBP; EEN-binding protein; SH3 domain protein D19; SH3 domain-containing protein 19; SH319_HUMAN; Sh3d19; SH3D19 protein. Research Area Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Rat, (predicted: Human, Dog, Cow, Horse, Sheep, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 86kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SH3D19 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Function:
May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1.
Subcellular Location:
Cytoplasm. Nucleus. Is recruited to the nucleus by the MLL-EEN fusion protein;.
Tissue Specificity:
Widely expressed with highest levels in heart, skeletal muscle, kidney, liver, placenta, small intestine and lung. Expressed at low levels in colon, thymus, spleen and leukocytes.
Similarity:
Contains 5 SH3 domains.
Database links:
Entrez Gene: 100727056 Guinea pig
Entrez Gene: 100062398 Horse
Entrez Gene: 152503 Human
Entrez Gene: 100353862 Rabbit
Omim: 608674 Human
SwissProt: Q5HYK7 Human
Unigene: 728240 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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