Product Name	Anti-SMTNL1/AF555
Chinese Name	AF555标记的平滑肌样蛋白1抗
Alias	Calponin homology associated smooth muscle protein; CHASM; OTTHUMP00000235021; Smoothelin like 1; Smoothelin like protein 1; SMTNL1.
Research Area	Cell biology  Signal transduction  transcriptional regulatory factor  Cytoskeleton  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	49kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SMTNL1
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
Product Detail	background: SMTNL1, which is a member of the smoothelin (SMTN; MIM 602127) family, regulates contraction and relaxation of skeletal and smooth muscle fibers and mediates vascular adaptation to exercise (Wooldridge et al., 2008 [PubMed 18310078]).[supplied by OMIM, Dec 2010] Function: Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity). Subcellular Location: Cytoplasm ?myofibril. Cytoplasm ?myofibril ?sarcomere ?I band By similarity. Cytoplasm ?myofibril ?sarcomere ?M line. Nucleus. Note: Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm. Phosphorylation at Ser-301 promotes translocation to the nucleus, Tissue Specificity: Expressed in striated muscles, specifically in type 2a fibers (at protein level). Post-translational modifications: Maximal phosphorylation of Ser-299 correlates with maximal relaxation of aorta in response to acetylcholine. Similarity: Belongs to the smoothelin family. Contains 1 CH (calponin-homology) domain. Database links: Entrez Gene: 219537 Human Omim: 613664 Human SwissProt: A8MU46 Human Unigene: 68756 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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