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Product Name Anti-MACROD2/C20orf133/AF555 Chinese Name AF555标记的20号染色体开放阅读框133抗体 Alias C20orf133; MACD2_HUMAN; MACRO domain containing 2; MACRO domain-containing protein 2; macrod2; O-acetyl-ADP-ribose deacetylase MACROD2. Research Area Cell biology Signal transduction Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 50kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MACROD2/C20orf133 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
MACROD2 (MACRO Domain Containing 2) is a Protein Coding gene. Diseases associated with MACROD2 include autism spectrum disorder and pervasive developmental disorder. GO annotations related to this gene include hydrolase activity, acting on glycosyl bonds and deacetylase activity. An important paralog of this gene is MACROD1.
Function:
Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins.
Subunit:
Interacts with ADP-ribosylated PARP1.
Subcellular Location:
Nucleus.
Similarity:
Contains 1 Macro domain.
Database links:Entrez Gene: 140733 Human
Entrez Gene: 72899 Mouse
SwissProt: A1Z1Q3 Human
SwissProt: Q3UYG8 Mouse
Unigene: 661576 Human
Unigene: 229466 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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