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Rabbit Anti-MACROD2/C20orf133/AF555 Conjugated antibody
Rabbit Anti-MACROD2/C20orf133/AF555 Conjugated antibody
C20orf133; MACD2_HUMAN; MACRO domain containing 2; MACRO domain-containing protein 2; macrod2; O-acetyl-ADP-ribose deacetylase MACROD2.
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  • NO.:SL18603R-AF555
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Mouse,(predicted: Human,)
    Applications:ICC IF
    concentration:1mg/ml
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Product Name Anti-MACROD2/C20orf133/AF555
Chinese Name AF555标记的20号染色体开放阅读框133抗体
Alias C20orf133; MACD2_HUMAN; MACRO domain containing 2; MACRO domain-containing protein 2; macrod2; O-acetyl-ADP-ribose deacetylase MACROD2.  
Research Area Cell biology  Signal transduction  Epigenetics  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Mouse,  (predicted: Human, )
Applications ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 50kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human MACROD2/C20orf133
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
MACROD2 (MACRO Domain Containing 2) is a Protein Coding gene. Diseases associated with MACROD2 include autism spectrum disorder and pervasive developmental disorder. GO annotations related to this gene include hydrolase activity, acting on glycosyl bonds and deacetylase activity. An important paralog of this gene is MACROD1.

Function:
Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins.

Subunit:
Interacts with ADP-ribosylated PARP1.

Subcellular Location:
Nucleus.

Similarity:
Contains 1 Macro domain.

Database links:

Entrez Gene: 140733 Human

Entrez Gene: 72899 Mouse

SwissProt: A1Z1Q3 Human

SwissProt: Q3UYG8 Mouse

Unigene: 661576 Human

Unigene: 229466 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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