Product Name	Anti-INTS4/AF555
Chinese Name	AF555标记的INTS4蛋白抗体
Alias	Int4; INT4_HUMAN; Integrator complex subunit 4; ints4; MGC16733; MST093; MSTP093; RGD1305036.
Research Area	Cell biology  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	108kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human INTS4
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008] Function: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Subcellular Location: Nucleus. Similarity: Belongs to the Integrator subunit 4 family. Contains 8 HEAT repeats. Database links: Entrez Gene: 100712822 Guinea pig Entrez Gene: 92105 Human Entrez Gene: 101861 Mouse Entrez Gene: 100512005 Pig Entrez Gene: 100350308 Rabbit Entrez Gene: 308837 Rat Omim: 611348 Human SwissProt: Q96HW7 Human SwissProt: Q8CIM8 Mouse Unigene: 533723 Human Unigene: 27383 Mouse Unigene: 1948 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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