TEL: +86 571 56623320 EMAIL: [email protected]
Product Name Anti-HISPPD2A/IP6 Kinase/AF555 Chinese Name AF555标记的组氨酸酸性磷酸酶结构域蛋白2A抗体 Alias Histidine acid phosphatase domain-containing protein 2A; hsVIP1; Inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinase 1; Inositol pyrophosphate synthase 1; InsP6 and PP IP5 kinase 1; IP6 kinase; IP6K; IPS1; PP IP5 kinase 1; PPIP5K1; VIP1. Research Area Cell biology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 159kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human HISPPD2A Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15.[provided by RefSeq, Jun 2010]
Function:
Bifunctional inositol kinase that catalyzes the formation of diphosphoinositol pentakisphosphate (InsP7 or PP-InsP5) and bi-diphosphoinositol tetrakisphosphate (InsP8 or PP2-InsP4). Converts inositolitol hexakisphosphate (InsP6) to InsP7. Also able to convert InsP7 to InsP8. Probably specifically mediates the formation of 4PP-InsP5 and 6PP-InsP5 InsP7 isomers but not of 5PP-IP5 InsP7 isomer. Activated when cells are exposed to hyperosmotic stress.
Subcellular Location:
Cytoplasm, cytosol.
Tissue Specificity:
Widely expressed, with a higher expression in skeletal muscle, heart and brain.
Similarity:
Belongs to the histidine acid phosphatase family. VIP1 subfamily.
Database links:Entrez Gene: 9677 Human
Omim: 610979 Human
SwissProt: Q6PFW1 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Scan Wechat Qrcode