Product Name	Anti-EXOC8/AF555
Chinese Name	AF555标记的EXOC8蛋白抗体
Alias	EXO84; Exo84p; exoc8; EXOC8_HUMAN; Exocyst complex 84 kDa subunit; Exocyst complex component 8; SEC84.
Research Area	Cell biology  Signal transduction  Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Cow, Horse, Rabbit, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	82kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human EXOC8
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Exocytosis is crucial in membrane trafficking and it mediates hormone and neurotransmitter secretion out of the cell, as well as the incorporation of membrane proteins and lipids to the plasma membrane. It is crucial for cell-cell communication, cell growth and cell polarity. The exocyst complex is a multi-protein complex that consists of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70 and Exo84, and is essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. The exocyst complex inhibits tubulin polymerization in vitro, suggesting that the exocyst complex is important for modulating the microtubule dynamics that underlie exocytosis. Exo84 (Exocyst complex 84 kDa subunit), also known as Exocyst complex component 8, is a 725 amino acid protein that is one of eight protein subunits composing the mammalian exocyst complex. Both Exo84 and Sec5 are effector targets for active Ral GTPases, which are responsible for regulating exocyst complex activities. Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Subcellular Location: Cytoplasm. Cell projection > growth cone. Redistributes to growing neurites and growth cones during cell differentiation (By similarity). Binds lipids with phosphatidylinositol-3,4,5-trisphosphate groups. Similarity: Belongs to the EXO84 family. Contains 1 PH domain. Database links: Entrez Gene: 149371 Human Entrez Gene: 102058 Mouse Omim: 615283 Human SwissProt: Q8IYI6 Human SwissProt: Q6PGF7 Mouse Unigene: 356198 Human Unigene: 347360 Mouse Unigene: 392449 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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