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Rabbit Anti-CRLS1/AF555 Conjugated antibody
Rabbit Anti-CRLS1/AF555 Conjugated antibody
0610009I22Rik; 4930557M15Rik; 5730490M08; C20orf155; Cardiolipin synthase 1; Cardiolipin synthase; CLS; CLS1; CRLS1; CRLS1_HUMAN; dJ967N21.6; GCD10; OTTMUSP00000016677; Protein GCD10 homolog; RGD1311037; RP23-77H16.4.
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  • NO.:SL14063R-AF555
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,)
    Applications:ICC IF
    concentration:1mg/ml
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Product Name Anti-CRLS1/AF555
Chinese Name AF555标记的心磷脂合成酶1抗体
Alias 0610009I22Rik; 4930557M15Rik; 5730490M08; C20orf155; Cardiolipin synthase 1; Cardiolipin synthase; CLS; CLS1; CRLS1; CRLS1_HUMAN; dJ967N21.6; GCD10; OTTMUSP00000016677; Protein GCD10 homolog; RGD1311037; RP23-77H16.4.  
Research Area Tumour  Cardiovascular  Cell biology  Signal transduction  The new supersedes the old  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
Applications ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 33kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human CRLS1
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
Cardiolipin synthetase is a mitochondrial protein that belongs to the CDP-alcohol phosphatidyltransferase class-I family. CLS1 is a multi-pass membrane protein localized to the inner membrane of mitochondria. CLS1 is responsible for the catalyzing the reversible transfer of a phosphatidyl group from one phosphatidyl glycerol molecule to another. This process results in the formation of cardiolipin (CL, or diphosphatidyl glycerol) and glycerol. Diphosphatidyl glycerol is a major component of the mitochondrial membrane and constitutes roughly 20% of total mitochondrial lipids. Having four fatty acid tails rather than the usual two, CL is a double phospholipid that is synthesized in the mitochondrion itself. Defects in the CRLS1 gene are likely to effect metabolism, sustained production of ATP and could contribute to diseases such as Barth syndrome.

Function:
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.

Subcellular Location:
Mitochondrion inner membrane.

Tissue Specificity:
Highly expressed in tissues such as heart, skeletal muscle and liver.

Similarity:
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Database links:

Entrez Gene: 54675 Human

Omim: 608188 Human

SwissProt: Q9UJA2 Human

Unigene: 224764 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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