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Product Name Anti-Ribonuclease 6/AF555 Chinese Name AF555标记的核糖核酸酶6抗体 Alias Ribonuclease T2; RNASE6PL; RP11 514O12.3; RNASET2; RNASE6PL; RNT2_HUMAN. Research Area Tumour Cell biology immunology Signal transduction Apoptosis transcriptional regulatory factor Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 27kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human RelB Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. There are 2 isoforms produced by alternative splicing.
Subcellular Location:
Secreted. Note=Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction.
Tissue Specificity:
Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.
DISEASE:
Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly (LCWM) [MIM:612951]. An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications.
Similarity:
Belongs to the RNase T2 family.
Database links:Entrez Gene: 8635 Human
Entrez Gene: 100037283 Mouse
Entrez Gene: 68195 Mouse
Omim: 612944 Human
SwissProt: O00584 Human
SwissProt: Q9CQ01 Mouse
Unigene: 529989 Human
Unigene: 181237 Mouse
Unigene: 426736 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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