Product Name	Anti-NIR1/AF555
Chinese Name	AF555标记的膜相关磷脂Transporter抗体
Alias	membrane-associated 3; CORD5; Membrane associated phosphatidylinositol transfer protein 3; Membrane-associated phosphatidylinositol transfer protein 3; NIR 1; NIR-1; NIR1; Phosphatidylinositol transfer protein; Phosphatidylinositol transfer protein, membrane-associated 3; PITM3_HUMAN; PITPnm 3; PITPNM; PITPNM family member 3; Pitpnm3; PYK2 N terminal domain interacting receptor 1; PYK2 N-terminal domain-interacting receptor 1; RDGBA3; retinal degeneration B alpha 3.
Research Area	Cell biology  immunology  Neurobiology  Signal transduction  transcriptional regulatory factor  Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Horse, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	106kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NIR1/RDGBA3
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions. Involvement in disease: Defects in PITPNM3 are the cause of cone-rod dystrophy type 5 (CORD5) . CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. Function: Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions. Subunit: Interacts with PTK2B via its C-terminus. Subcellular Location: Endomembrane system; Peripheral membrane protein Tissue Specificity: Detected in brain and spleen, and at low levels in ovary. DISEASE: Defects in PITPNM3 are the cause of cone-rod dystrophy type 5 (CORD5) [MIM:600977]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. Similarity: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. Contains 1 DDHD domain. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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