Product Name	Anti-NSL1/AF488
Chinese Name	AF488标记的着丝粒相关蛋白NSL1抗体
Alias	4833432M17Rik; AI451597; C1orf48; DC31; DC8; DKFZp566O1646; Gm105; Gm984; Kinetochore associated protein NSL1 homolog; Kinetochore-associated protein NSL1 homolog; MIS14; NSL1; NSL1, MIND kinetochore complex component, homolog (S. cerevisiae); NSL1_HUMAN.
Research Area	Cell biology  Chromatin and nuclear signals  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	32kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NSL1
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014] Function: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. Subunit: Component of the MIS12 complex composed of MIS12, DSN1, NSL1/DC8 and PMF1. Interacts with CASC5. Subcellular Location: Nucleus. Chromosome > centromere > kinetochore. Associated with the kinetochore. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Database links: Entrez Gene: 25936 Human SwissProt: Q96IY1 Human Unigene: 497692 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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