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Product Name Anti-Hey L/AF488 Chinese Name AF488标记的转录因子HRT3抗体 Alias bHLHb33; Class B basic helix loop helix protein 33; Class B basic helix-loop-helix protein 33; Hairy enhancer of split related with YRPW motif like; Hairy related transcription factor 3; Hairy-related transcription factor 3; Hairy/enhancer of split related with YRPW motif 3; Hairy/enhancer of split related with YRPW motif like; Hairy/enhancer of split related with YRPW motif like protein; Hairy/enhancer-of-split related with YRPW motif-like protein; HEY like protein; HEY3; HEYL; HEYL protein; HEYL_HUMAN; hHeyL; hHRT3; HRT 3; HRT-3; HRT3; MGC12623. Research Area Cardiovascular Cell biology Neurobiology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 35kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Hey L Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Function:
Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the HEY family.
Contains 1 basic helix-loop-helix (bHLH) domain.
Contains 1 Orange domain.
Database links:Entrez Gene: 26508 Human
Entrez Gene: 56198 Mouse
SwissProt: Q9NQ87 Human
SwissProt: Q9DBX7 Mouse
Unigene: 472566 Human
Unigene: 103615 Mouse
Unigene: 22252 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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