Product Name	Anti-ZNF93/AF488
Chinese Name	AF488标记的Zinc finger protein93抗体
Alias	FLJ12488; HPF34; HTF34; TF34; Zinc finger protein 505; Zinc finger protein 93 (HTF34); Zinc finger protein 93; Zinc finger protein HTF34; ZNF505; ZNF93; ZNF93_HUMAN.
Research Area	Cell biology  Signal transduction  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	71kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ZBT24/ZNF45
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5 end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305). Function: May be involved in transcriptional regulation. Subcellular Location: Nucleus. DISEASE: Expressed early during embryonic development. Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 17 C2H2-type zinc fingers. Contains 1 KRAB domain. Database links: Entrez Gene: 81931 Human Omim: 603975 Human SwissProt: P35789 Human Unigene: 301059 Human Unigene: 723768 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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