Product Name	Anti-MRP3/AF488
Chinese Name	AF488标记的多药耐药相关蛋白3抗体
Alias	ABC 31; ABC31; ABCC 3; ABCC3; ATP binding cassette sub family C (CFTR/MRP) member 3; ATP binding cassette sub family C; ATP binding cassette sub family C member 3; Canalicular multispecific organic anion transporter 2; Canicular multispecific organic anion transporter; CMOAT 2; CMOAT2; EST90757; MLP 2; MLP2; MOAT D; MOATD; MRP 3; Multi specific organic anion transporter D; Multidrug resistance associated protein 3; Multidrug resistance associated protein; Multispecific organic anion tranporter D.
Research Area	Tumour  Cell biology  Signal transduction  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Cow, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	190kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MRP3
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] Function: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney. Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains. Database links: Entrez Gene: 8714 Human Entrez Gene: 76408 Mouse Entrez Gene: 140668 Rat Omim: 604323 Human SwissProt: O15438 Human SwissProt: B2RX12 Mouse SwissProt: O88563 Rat Unigene: 463421 Human Unigene: 23942 Mouse Unigene: 205054 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. MRP3 (multidrug resistance protein 3)在正常epithelial cells：如；消化道，气管支气管，膀胱、肾上腺和睾丸组织中有不同的表达，在各种组织的基质细胞中也有程度不同的表达，在Tlymphocyte中表达较高，而原始造血Stem cells中则无表达。 MRP3又称ABCC3主要用于非PglycoproteinMDRTumour细胞系的Tumour耐药性的研究。 经研究发现MRP的同源性较高，他包括：MRP1、 MRP2、MRP3、MRP4和MRP5、MRP6和MRP7，都有部分交叉同源。

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