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Rabbit Anti-WNT10A/AF488 Conjugated antibody
Rabbit Anti-WNT10A/AF488 Conjugated antibody
wingless-type MMTV integration site family, member 10A; WNT 10A; WNT10 A; WNT10A; Protein Wnt-10a; WN10A_HUMAN.
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  • NO.:SL1947R-AF488
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,)
    Applications:IF
    concentration:1mg/ml
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Details

Product Name Anti-WNT10A/AF488
Chinese Name AF488标记的信号通路WNT10A抗体
Alias wingless-type MMTV integration site family, member 10A; WNT 10A; WNT10 A; WNT10A; Protein Wnt-10a; WN10A_HUMAN.  
Research Area Tumour  Cell biology  Signal transduction  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
Applications IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 42kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human WNT10A
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Similarity:
Belongs to the Wnt family.

Database links:

Entrez Gene: 80326 Human

Entrez Gene: 22409 Mouse

Omim: 606268 Human

SwissProt: Q9GZT5 Human

SwissProt: P70701 Mouse

Unigene: 121540 Human

Unigene: 5130 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Wnt通路与人类多种Tumour的发生有关,WNT10A主要用于消化系统Tumour的研究。

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