Product Name	Anti-DEPDC1/AF488
Chinese Name	AF488标记的细胞周期调控蛋白SDP35抗体
Alias	Cell cycle control protein SDP35; DEP domain containing 1; DEP domain containing protein 1A; DEP domain-containing protein 1A; DEP.8; DEP1A_HUMAN; DEPDC 1; DEPDC 1A; DEPDC1; DEPDC1-V2; Depdc1a; FLJ20354; SDP 35; SDP35.
Research Area	Tumour  TumourCell biologyMaker
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	93kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DEPDC1 (606-660aa)
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: DEPDC1 is a 784 amino acid nuclear protein expressed in testis and up-regulated in bladder cancer cells. Containing a DEP domain and a Rho-GAP domain, DEPDC1 may play an essential role in the growth of bladder cancer cells, and is considered a novel protein target for bladder cancer therapy. Existing as five isoforms produced by alternative splicing events, DEPDC1 is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma Function: May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. Subunit: Isoform 2 and isoform 5 can form homodimers and heterodimers. Interacts with ZNF224. Subcellular Location: Nucleus. Note=Co-localizes with ZNF224 at the nucleus. Tissue Specificity: Expressed in testis. Up-regulated in bladder cancer cells (at protein level). Similarity: Contains 1 DEP domain. Contains 1 Rho-GAP domain. Database links: Entrez Gene: 55635 Human Omim: 612002 Human SwissProt: Q5TB30 Human Unigene: 445098 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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