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Product Name Anti-ICAM5/AF488 Chinese Name AF488标记的细胞间粘附分子5抗体 Alias ICAM5_HUMAN; ICAM5 precursor; Intercellular adhesion molecule 5; Intercellular adhesion molecule 5 precursor; Intercellular adhesion molecule 5, telencephalin; Telencephalin; TLCN; TLN. Research Area Cell biology immunology Neurobiology Cell adhesion molecule Cell type markers Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Cow, ) Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 97kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human ICAM5 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
ICAM5 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.
Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.
Similarity:
Belongs to the immunoglobulin superfamily. ICAM family.
Contains 9 Ig-like C2-type (immunoglobulin-like) domains.
Database links:
UniProtKB/Swiss-Prot: Q9UMF0.3
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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