Product Name	Anti-FEM1A/AF488
Chinese Name	AF488标记的前列腺素E受体4相关蛋白抗体
Alias	EPRAP; Fem-1 homolog a (C. elegans); Fem1 homolog a; FEM1-alpha-A; FEM1a-A; Fem1aa; Feminization 1 homolog a (C. elegans); Feminization 1 homolog a; Prostaglandin E receptor 4-associated protein; Protein fem-1 homolog A; Protein fem-1 homolog A-A; FEM1A_HUMAN.
Research Area	Cell biology  Signal transduction  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	74kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FEM1A
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: FEM1A is a caspase substrate homologous to the C. Elegans sex determining protein, FEM-1. Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. May participate in antiinflammatory signaling via its interaction with PTGER4. Overexpression of FEM1A in mammalian cells is reported to induce apoptosis. Function: Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. May participate in antiinflammatory signaling via its interaction with PTGER4. Subunit: Component of some E3 ubiquitin-protein ligase complex. Interacts with PTGER4. Subcellular Location: Cytoplasm (Probable). Tissue Specificity: Present in macrophages derived from peripheral blood monocytes. Also present in atheromata (at protein level). Similarity: Belongs to the fem-1 family. Contains 9 ANK repeats. Contains 2 TPR repeats. Database links: Entrez Gene: 516550 Cow Entrez Gene: 55527 Human Entrez Gene: 14154 Mouse Entrez Gene: 316131 Rat GenBank: NP_061178.1 Human SwissProt: Q29RM5 Cow SwissProt: Q9BSK4 Human SwissProt: Q8C4V3 Mouse SwissProt: Q4V890 Rat Unigene: 515082 Human Unigene: 290813 Mouse Unigene: 228392 Rat Unigene: 97265 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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