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Rabbit Anti-DOM3Z/AF488 Conjugated antibody
Rabbit Anti-DOM3Z/AF488 Conjugated antibody
Dom 3 homolog Z; DOM 3Z; Dom-3 homolog Z; DOM3 C. elegans homolog of Z; Dom3 homolog Z; DOM3L; Dom3z; DOM3Z_HUMAN; NG6; Protein Dom3Z.
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Details

Product Name Anti-DOM3Z/AF488
Chinese Name AF488标记的DOM3Z蛋白抗体
Alias Dom 3 homolog Z; DOM 3Z; Dom-3 homolog Z; DOM3 C. elegans homolog of Z; Dom3 homolog Z; DOM3L; Dom3z; DOM3Z_HUMAN; NG6; Protein Dom3Z.  
Research Area Cell biology  immunology  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, )
Applications IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 45kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human DOM3Z
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
DOM3Z, also known as NG6 or DOM3L, is a 396 amino acid ubiquitously expressed protein belonging to the Dom3Z family. The gene encoding DOM3Z maps to human chromosome 6 in the major histocompatibility complex (MHC) class III region. Chromosome 6 contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease and Stickler syndrome are all associated with genes that map to chromosome 6.

Function:
May possess pyrophosphohydrolase activity towards 5' triphosphorylated RNA (By similarity).

Tissue Specificity:
Ubiquitously expressed

Similarity:
Belongs to the Dom3Z family.

Database links:

Entrez Gene: 508460 Cow

Entrez Gene: 1797 Human

Entrez Gene: 112403 Mouse

Entrez Gene: 100124385 Pig

Entrez Gene: 361799 Rat

Omim: 605996 Human

SwissProt: Q5E9Y5 Cow

SwissProt: O77932 Human

SwissProt: O70348 Mouse

SwissProt: Q6MG77 Rat

Unigene: 153299 Human

Unigene: 275309 Mouse

Unigene: 20463 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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