Product Name	Anti-ASZ1/AF488
Chinese Name	AF488标记的锚定蛋白样蛋白1抗体
Alias	Ankyrin repeat, SAM and basic leucine zipper domain containing protein 1; Ankyrin repeat, SAM and basic leucine zipper domain containing protein 1; ALP1; ANKL1; Ankyrin like protein 1; ASZ 1; ASZ1_HUMAN.
Research Area	Tumour  Cardiovascular  Cell biology  Neurobiology  Signal transduction  Cyclin  Kinases and Phosphatases  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Horse, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	53kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ASZ1
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: ASZ1 (ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1), also known as ANKL1, ALP1 (Ankyrin-like protein 1), GASZ (germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein) or Orf3, is a 475 amino acid protein that is suggested to function as a signal transducer during germ cell maturation. Localized to the cytoplasm of pachytene spermatocytes, early spermatids and oocytes, ASZ1 is primarily found in adult testis and ovary where it mediates protein-protein interactions. ASZ1 contains six ANK repeats, one SAM (sterile alpha motif) domain and is encoded by a gene located on human chromosome 7q31, a region that may have an important role in the development certain types of human cancer. Function: Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity). Subunit: Interacts with DDX4, PIWIL1, RANBP9 and TDRD1 (By similarity). Subcellular Location: Cytoplasm (By similarity). Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Specifically localizes to pi-bodies, a subset of the nuage which contains primary piRNAs (By similarity). Tissue Specificity: Expressed exclusively in the testis and ovary and at higher levels in the adult testis compared with the adult ovary. Similarity: Contains 6 ANK repeats. Contains 1 SAM (sterile alpha motif) domain. Database links: Entrez Gene: 136991 Human SwissProt: Q8WWH4 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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