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Product Name Anti-SURF5/AF350 Chinese Name AF350标记的过量位点蛋白5抗体 Alias MED22; MED22_HUMAN; MED24; Mediator complex subunit 22; Mediator of RNA polymerase II transcription subunit 22; OTTHUMP00000022480; OTTMUSP00000012503; RGD1564893; Surf 5; Surf-5; Surfeit 5; Surfeit locus protein 5. Research Area Cell biology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Sheep, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 22kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SURF5 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factors. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the Mediator complex subunit 22 family.
Database links:Entrez Gene: 417159 Chicken
Entrez Gene: 6837 Human
Entrez Gene: 20933 Mouse
Entrez Gene: 415234 Zebrafish
Omim: 185641 Human
SwissProt: Q800L3 Chicken
SwissProt: Q15528 Human
SwissProt: Q62276 Mouse
SwissProt: A5WUL3 Zebrafish
Unigene: 78354 Human
Unigene: 397932 Mouse
Unigene: 202721 Rat
Unigene: 15892 Zebrafish
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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