Product Name	Anti-LRTOMT/LRRC51/AF350
Chinese Name	AF350标记的富含亮氨酸重复蛋白51抗体
Alias	COMT2; DFNB63; Leucine rich repeat-containing protein 51; Leucine rich transmembrane and 0-methyltransferase domain containing; LRRC51; LRTOMT1; LRTOMT2; Protein LRTOMT1.
Research Area	Cell biology  immunology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, hu, mo, rat, dog)
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	22kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LRTOMT/LRRC51
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene includes two transcript forms. The short form has one open reading frame (ORF), which encodes the leucine-rich repeats (LRR)-containing protein of unknown function. This protein is called LRTOMT1 or LRRC51. The long form has two alternative ORFs; the upstream ORF has the same translation start codon as used in the short form and the resulting transcript is a candidate for nonsense-mediated decay, and the downstream ORF encodes a different protein, which is a transmembrane catechol-O-methyltransferase and is called LRTOMT2, TOMT or COMT2. The COMT2 is essential for auditory and vestibular function. Defects in the COMT2 can cause nonsyndromic deafness. Alternatively spliced transcript variants from each transcript form have been found for this gene. [provided by RefSeq, Sep 2012] Subcellular Location: Cytoplasmic Similarity: Contains 3 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Database links: Entrez Gene: 220074 Human Entrez Gene: 69358 Mouse Omim: 612414 Human SwissProt: Q96E66 Human SwissProt: Q9DAK8 Mouse SwissProt: B6CZ61 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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