Product Name	Anti-TNPO2/AF350
Chinese Name	AF350标记的Transporter2抗体
Alias	Importin 3; IPO3; Karyopherin beta 2b, transportin; KPNB2B; TNPO2; Transportin 2 (importin 3, karyopherin beta 2b); Transportin 2 (Importin 3, karyopherin beta 2b), isoform CRA b; Transportin 2; TRN2.
Research Area	Cell biology  immunology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	60, 100kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TNPO2
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Protein transport across the nucleus is a selective, multi-step process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Two cytosolic factors centrally involved in the recognition and docking process are the karyopherin alpha 1 and karyopherin beta1 subunits. Karyopherin alpha 1 functions in the recognition and targeting of substrates destined for nuclear import, while karyopherin beta 1 serves as an adapter, tethering the karyopherin alpha 1/substrate complex to docking proteins on the nuclear envelope, termed nucleoporins. Karyopherin alpha 2 has been shown to complex with Epstein-Barr virus nuclear antigen 1 (EBNA-1). Karyopherin beta 2 and karyopherin beta 2B (also designated transportin 1 and transportin 2) share 84% sequence identity at the amino acid level, however, they have been shown to have different substrate specificities. Karyopherin beta 2 mediates hnRNPA1 nuclear import while karyopherin beta 2B has been implicated in the export of cellular mRNAs through complexes formed with the mRNA export factor TAP. Function: Transportin 2 (TNPO2) mediates nuclear import of HuR protein in vitro. It also participates in mRNA export from the nucleus. Subcellular Location: Cytoplasm Nucleus Similarity: Belongs to the importin beta family. Contains 13 HEAT repeats. Contains 1 importin N-terminal domain. Database links: Entrez Gene: 30000 Human Entrez Gene: 212999 Mouse Entrez Gene: 304670 Rat Omim: 603002 Human SwissProt: O14787 Human SwissProt: Q6IN77 Human SwissProt: Q99LG2 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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